Piperine, an active ingredient of black pepper attenuates acetaminophen–induced hepatotoxicity in mice
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چکیده
منابع مشابه
Adiposity suppression effect in mice due to black pepper and its main pungent component, piperine.
We investigated energy metabolism enhancement by pepper by examining suppression of body fat accumulation in mice due to piperine (PIP) and black pepper (BP) intake. To induce adiposity, mice were fed a high-fat, high-sucrose (HFS) diet as a control diet for 4 weeks. Visceral fat weights decreased significantly in the mice fed diets of 0.03% and of 0.05% PIP. Body weight in the 0.05% PIP group ...
متن کاملPiperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation.
An extract from the fruits of black pepper consisting of a minimum of 98% pure piperine was evaluated in a clinical study using a double-blind design. The relative bioavailability of 90 mg and 120 mg of coenzyme Q10 administered in a single-dose experiment or in separate experiments for 14 and 21 days with placebo or with 5 mg of piperine was determined by comparing measured changes in plasma c...
متن کاملPiperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4.
Dietary constituents (e.g., in grapefruit juice; NaCl) and phytochemicals (e.g., St. John's wort) are important agents modifying drug metabolism and transport and thereby contribute to interindividual variability in drug disposition. Most of these drug-food interactions are due to induction or inhibition of P-glycoprotein and/or CYP3A4. Preliminary data indicate that piperine, a major component...
متن کاملNew Method Development for Extraction and Isolation of Piperine from Black Pepper
Piperine, a major alkaloid in black pepper is one of the most promising bioenhancers till date. Other methods used for its extraction suffer drawbacks such as poor extraction efficiency, tedious and expensive isolation methodology, piperine photodegradation, etc. Hence a simple, rapid and efficient method has been developed for the isolation of piperine from the fruits of Piper nigrum. The meth...
متن کاملThe analgesic and anticonvulsant effects of piperine in mice.
Piperine, is the major active principal of black pepper. In traditional medicine, black pepper has been used as an analgesic, anti-inflammatory agent and in the treatment of epilepsy. This study was conducted to evaluate the in vivo analgesic and anticonvulsant effects of piperine in mice. The analgesic and anticonvulsant effects of piperine were studied in mice using acetic acid-induced writhi...
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ژورنال
عنوان ژورنال: Asian Pacific Journal of Tropical Medicine
سال: 2010
ISSN: 1995-7645
DOI: 10.1016/s1995-7645(11)60011-4